These specialized neurons act as a crucial intermediary within the retina, situated between photoreceptor cells (rods and cones) and ganglion cells. They receive signals directly from the photoreceptors or from horizontal cells, which modulate the signal. Subsequently, the electrical signals are transmitted to the ganglion cells, the axons of which form the optic nerve, carrying visual information to the brain. As an example, consider a bright light stimulating a cone photoreceptor; this excitation may trigger the activity of one type of these neurons, signaling an “on” response, while simultaneously inhibiting the activity of another type, signaling an “off” response. This differential response contributes to edge detection and contrast enhancement in early visual processing.
The significance of these cells lies in their role as signal processors. They are not simply passive relay stations; they actively modify and refine the visual information, contributing to adaptation, contrast sensitivity, and color processing. Disruptions in their function, whether due to genetic factors, disease, or injury, can lead to various visual impairments. Historically, understanding their function has been essential for advancements in understanding the entire visual pathway and for the development of treatments for retinal diseases.